CEFUROXIME ANS, CEFUROXIME SXP (Southern Cross Pharma Pty Ltd)

CEFUROXIME ANS, CEFUROXIME SXP (powder for injection) is indicated in adults and children of 40 kg or greater in weight for the prevention of infections associated with certain surgical procedures of the gastrointestinal (including oesophageal), orthopaedic, cardiovascular and gynaecological systems (including caesarean section) (see SECTION 4.4: SPECIAL WARNINGS AND PRECAUTIONS FOR USE and SECTION 5.2: PHARMACOKINETIC PROPERTIES).

In the prevention of infections in which it is very likely that anaerobic organisms will be encountered, cefuroxime should be administered with additional appropriate antibacterial agents such as metronidazole.

Consideration should be given to official guidance on the appropriate use of antibacterial agents, as antibiotic prophylaxis is not required in all gastrointestinal, orthopaedic, cardiovascular and gynaecological procedures or surgeries.

For patients with specific cardiac conditions which predispose them to endocarditis who are undergoing abdominal surgery for which surgical antibiotic prophylaxis is indicated, the prophylaxis regimen should additionally include an antibiotic active against enterococci.

For patients undergoing orthopaedic or cardiovascular surgery known to be, or at risk of being, colonised or infected with methicillin-resistant S. aureus (MRSA), add an antibiotic with activity against MRSA, such as vancomycin.

CEFUROXIME ANS, CEFUROXIME SXP is not indicated in children < 40 kg in weight.